In April 2026, China officially released its first national consensus document: the Chinese Expert Consensus on the Role and Clinical Application of NAD⁺ in Aging-Related Diseases (2026 Edition).

Led by the Chinese Medical Association Geriatrics Branch and jointly developed by leading experts in aging medicine, metabolic disorders, cardiovascular disease, and neurology, this landmark consensus is the first in China to establish standardized clinical guidance for the application of NAD⁺ and its precursors (such as NMN and NR). It also provides graded recommendations and evidence-based administration strategies.

The publication of this consensus fills a major gap in clinical guidance for NAD⁺ anti-aging interventions in China, marking a transition from “blind supplementation” to a new era of evidence-based and precision application.

Today, let’s break down the key insights from this important consensus in the clearest and most practical way possible.

 

PART 01

Key Takeaway from the Expert Consensus:

Declining NAD⁺ Is the “Master Switch” Behind Aging and Chronic Disease

The latest 2026 Chinese expert consensus makes several critical conclusions unmistakably clear:

• As people age, NAD⁺ levels in the brain, heart, liver, skeletal muscle, and other tissues decline significantly by approximately 10%–50%. This is considered a universal hallmark of aging across species.
• NAD⁺ deficiency is directly associated with nearly all major age-related disorders, including metabolic diseases, cardiovascular diseases, neurodegenerative disorders, sarcopenia, and cancer.
• NAD⁺ supplementation may improve metabolism, protect cardiac function, slow muscle loss, support chemotherapy protection, and enhance neurological function, while generally demonstrating good safety and mild, controllable adverse effects.

In short:
If you want to age more slowly and reduce the risk of chronic disease, maintaining cellular NAD⁺ levels is essential.

 

PART 02

How Can NAD⁺ Be Supplemented?

Clinical Research Has Identified Three Scientific Pathways

The consensus clearly recommends three major strategies for increasing NAD⁺ levels in the body:

(1) Intravenous or Intramuscular Pharmaceutical-Grade NAD⁺

This method is recommended for rapid replenishment under specific clinical conditions. Direct administration bypasses metabolic bottlenecks and can significantly elevate circulating NAD⁺ levels.

(2) Oral NAD⁺ Precursors (Such as NMN and NR)

This approach is suitable for daily health management and general populations. The consensus particularly emphasizes the convenience and long-term maintenance benefits of these precursors.

(3) Lifestyle Intervention

Regular exercise and balanced nutrition can promote endogenous NAD⁺ synthesis by increasing NAMPT activity. The consensus even highlights a simple principle:

“Exercise is a natural and highly effective NAD⁺ booster.”

Among these approaches, NAD⁺ precursors have become the mainstream choice for anti-aging and daily wellness due to their safety, convenience, and bioavailability.

 

PART 03

Core Recommendations at a Glance

(Most Practical Summary)

(1) Metabolic Diseases

NAD⁺ supplementation may help improve insulin sensitivity, regulate lipid metabolism, and reduce low-density lipoprotein (LDL) levels, offering potential benefits for conditions such as fatty liver disease and diabetes.

(2) Cardiovascular Diseases

• Coronary artery disease / Myocardial infarction:
  NAD⁺ injection therapy may improve cardiac function and inhibit myocardial remodeling, with overall efficacy rates superior to control groups.
• Heart failure:
  Short-term intravenous NAD⁺ supplementation may significantly improve left ventricular ejection fraction (LVEF), cardiac performance indicators, and antioxidant capacity.

(3) Sarcopenia

NAD⁺ supplementation may help improve muscle strength and muscle mass while slowing age-related muscle degeneration.

(4) Neurodegenerative Diseases

NAD⁺ supplementation may provide mild improvement in motor symptoms among patients with Parkinson's Disease.
However, clinical evidence for Alzheimer's Disease remains insufficient.

(5) Cancer Therapy Support

Injectable Coenzyme I may reduce the incidence of chemotherapy-induced leukopenia and may help suppress tumor growth by enhancing anti-tumor immune responses.

The above represents only selected recommendations from the consensus.

 

PART 04

Conclusion: Anti-Aging Is Not a Mystery — It Is Science

The release of China’s first NAD⁺ expert consensus in 2026 officially moves NAD⁺ from the laboratory into frontline clinical practice. It clearly demonstrates that NAD⁺ is not merely an “anti-aging trend,” but rather a critical molecule involved in cellular energy metabolism, healthy aging, and chronic disease prevention.

Bontac Bio-Engineering has always believed that the true purpose of biotechnology is to transform cutting-edge life science into accessible health solutions for everyone.

Since pioneering the industrial-scale production of full-enzyme catalytic technology in 2012, Bontac Bio-Engineering has successfully reduced reliance on imported coenzyme raw materials and established a comprehensive product portfolio covering NMN, NR, NAD, NADP, NADH, NMNH, and other core NAD⁺ coenzymes, becoming an active contributor to industry standards and technological advancement.

The company has filed more than 200 invention patents, established China’s first provincial-level Coenzyme Engineering Technology Research Center, and been recognized as a national-level “Little Giant” enterprise specializing in advanced technologies. It has also obtained comprehensive certifications including SELF GRAS, FDA, DMF, FSSC22000, HALAL, KOSHER, ISO9001, and ISO14001, continuing to lead the field of synthetic biology.

Leveraging globally advanced enzymatic manufacturing technology, Bontac Bio-Engineering provides high-purity and highly stable NAD⁺ coenzyme ingredients, safeguarding pharmaceutical-grade quality from the source and supporting the future of clinical anti-aging applications.

On the journey toward healthy aging, science lights the way, and quality forms the foundation.
Bontac Bio-Engineering is committed to advancing healthy longevity together with you.