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Why Choose BONTAC?
Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
Unlocking the Secrets of NMN: Mechanism and Effects on Health
In the world of cutting-edge biotechnology, few compounds have garnered as much attention as Nicotinamide Mononucleotide, or NMN. This revolutionary molecule is taking the health and wellness industry by storm, and for a good reason. In this article, we will explore what NMN is, its mechanisms, and its profound effects on health.
What is NMN?
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound found in all living cells. It plays a crucial role in the production of Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme that is essential for various biological processes in the body. NAD+ levels tend to decline as we age, contributing to various age-related health issues. NMN supplementation aims to boost NAD+ levels, potentially reversing or mitigating these issues.
The Mechanism: How NMN Works
NMN is a precursor to NAD+, meaning it is converted into NAD+ in our cells. This transformation is vital because NAD+ is involved in several critical cellular functions, including energy metabolism, DNA repair, and gene expression. When NMN is administered, it enhances the NAD+ levels, providing the body with more of this essential coenzyme.
Effects of NMN on Health
The increased availability of NAD+ through NMN supplementation has far-reaching effects on health and wellness:
1、Energy Production: NAD+ is a key player in the production of adenosine triphosphate (ATP), the body's primary energy currency. More NAD+ means more energy for the body's cells, potentially leading to increased vitality and stamina.
2、Cellular Repair: NAD+ supports DNA repair mechanisms, helping to maintain the integrity of the genome. This is crucial in preventing mutations that can lead to aging and the development of diseases.
3、Sirtuin Activation: NAD+ is necessary for the activation of sirtuins, a family of proteins that regulate cellular health. Sirtuins have been associated with longevity and can help combat age-related issues.
4、Metabolic Health: Increased NAD+ levels can have a positive impact on metabolic processes, potentially aiding in weight management and preventing metabolic disorders.
5、Neuroprotection: Some studies suggest that NAD+ augmentation with NMN may help protect against neurodegenerative diseases like Alzheimer's and Parkinson's.
6、Cardiovascular Health: NAD+ plays a role in maintaining healthy blood vessels, which can contribute to cardiovascular health.
7、Immune System Support: NAD+ helps regulate the immune system, potentially enhancing its ability to respond to infections and diseases.
Is NMN Safe?
NMN is generally considered safe for use, and it has been extensively studied in animal models. However, more research is needed to fully understand its long-term effects in humans. As with any supplement, it's crucial to consult with a healthcare professional before incorporating NMN into your health regimen.
In conclusion, NMN is a remarkable compound with the potential to revolutionize health and wellness. By increasing NAD+ levels, NMN supplementation can positively impact energy levels, cellular repair, metabolic health, and more. As the biotechnology industry continues to explore the possibilities of NMN, it may become a key player in the quest for longevity and enhanced well-being.
At Bontac, we are at the forefront of providing high-quality NMN raw materials for businesses in the health and wellness industry. Our commitment to quality and innovation ensures that our partners can harness the full potential of NMN. Contact us to learn more about our NMN offerings and how we can assist your business in delivering cutting-edge products to the market.
NMN: Manufacturing, Preparation, and Clinical Trials
In the realm of cutting-edge biotechnology, one compound has taken center stage for its potential to transform the landscape of health and wellness. Nicotinamide Mononucleotide (NMN) has been the subject of significant research, with a focus on its manufacturing and preparation processes, as well as its clinical trials.
NMN Manufacturing and Preparation
NMN is a derivative of niacin (vitamin B3) and is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme involved in various cellular functions. Producing NMN involves several steps to ensure its purity and effectiveness:
1、Extraction: NMN can be synthesized from niacin or obtained through the extraction of natural sources like milk. These sources contain precursors that can be converted into NMN.
2、Purification: After extraction, NMN must undergo purification processes to remove impurities and achieve the desired level of purity. High purity is essential to ensure the efficacy and safety of NMN supplements.
3、Synthesis: Chemical synthesis is another method for manufacturing NMN. This involves converting niacin into NMN through a series of chemical reactions. This method offers precise control over the NMN production process.
4、Quality Control: Throughout the manufacturing process, rigorous quality control measures are applied to guarantee the safety and effectiveness of the final product. These measures include testing for purity, potency, and absence of contaminants.
The manufacturing and preparation of NMN require careful attention to detail to ensure that the end product meets the highest standards for quality and safety.
NMN Clinical Trials
Clinical trials related to NMN have provided valuable insights into its potential benefits. These trials have explored various aspects of NMN supplementation, shedding light on its safety and effectiveness:
1、Aging and Longevity: Some studies have suggested that NMN supplementation may have a positive impact on aging-related issues, potentially extending lifespan and improving overall health.
2、Metabolic Health: Clinical trials have examined the effects of NMN on metabolic health. Preliminary results have indicated potential benefits in areas such as glucose metabolism and insulin sensitivity.
3、Cardiovascular Health: Research has investigated the impact of NMN on cardiovascular health. Promising findings have emerged regarding blood vessel function and blood pressure regulation.
4、Neuroprotection: NMN's potential neuroprotective properties have been studied in the context of neurodegenerative diseases. While more research is needed, early results have been encouraging.
5、Safety and Tolerability: Clinical trials have also focused on the safety and tolerability of NMN. Generally, NMN has been well-tolerated, with few reported side effects.
It's important to note that while these clinical trials have provided valuable data, the research on NMN is ongoing, and more extensive studies are needed to establish its long-term safety and efficacy.
Bontac, a leading biotech enterprise, is at the forefront of providing high-quality NMN raw materials. Our commitment to innovation and quality ensures that our partners can develop products that meet the highest standards in the health and wellness industry. With a strong emphasis on research and development, we aim to contribute to the ongoing exploration of NMN's potential benefits.
In conclusion, NMN manufacturing and preparation involve a series of rigorous steps to ensure the production of high-quality, safe supplements. Clinical trials have provided promising insights into NMN's potential benefits in areas such as aging, metabolic health, cardiovascular health, and neuroprotection. As research on NMN continues, Bontac remains dedicated to providing the industry with the finest NMN raw materials for the development of innovative health and wellness products.
Best NMN Powder: Factory, Purity, and Supplier
When searching for the best NMN (Nicotinamide Mononucleotide) powder, three key aspects play a pivotal role in your decision-making process. This comprehensive guide dives into the world of NMN, highlighting the critical factors that set the best NMN powder apart. We'll explore the best NMN powder factory, delve into the significance of purity, and introduce you to a reliable NMN powder supplier.
- Best NMN Powder Factory :
- State-of-the-Art Manufacturing:
The foundation of premium NMN powder begins at the factory. Look for a manufacturer that boasts state-of-the-art facilities, adhering to the highest standards of production. Top-tier factories utilize cutting-edge technology and rigorous quality control to ensure the finest NMN powder.
- Research and Development:
Leading NMN powder factories invest in robust research and development. They actively engage in scientific studies and collaborate with experts to continuously enhance their product's quality and effectiveness.
- Quality Certifications:
Reputable factories hold certifications such as GMP (Good Manufacturing Practices) and ISO, underscoring their commitment to quality, safety, and consistency. These certifications are a testament to their dedication to producing the best NMN powder.
- Best NMN Powder Purity (approx. 200 words):
- High Purity Standards:
The purity of NMN powder is paramount. Opt for a product with a purity rating of 99% or higher. The best NMN powder is free from impurities and excipients, ensuring maximum potency.
- Independent Testing:
To validate purity claims, the best NMN powder undergoes independent third-party testing. These tests provide transparency and assurance that what you're purchasing aligns with its purity claims.
- No Additives or Fillers:
A top-quality NMN powder doesn't contain additives or fillers. The absence of unnecessary substances ensures you're receiving a pure and potent product.
- Best NMN Powder Supplier:
- Reliability and Reputation:
Selecting the right supplier is crucial. Look for a supplier with a stellar reputation for delivering consistent, high-quality NMN powder. Online reviews and testimonials can offer insights into their reliability.
- Transparent Sourcing:
A trustworthy supplier should be transparent about the sourcing and production of their NMN powder. Clear information about their supply chain and production process demonstrates their commitment to quality.
- Customer Support:
The best NMN powder supplier offers excellent customer support. Whether you have questions or need assistance, a responsive and knowledgeable support team is a valuable asset.
In the quest for the best NMN powder, the factory, purity, and supplier are non-negotiable elements. By opting for a manufacturer with cutting-edge facilities, a commitment to purity, and a reliable supplier with a sterling reputation, you'll embark on a journey towards reaping the full benefits of NMN. The best NMN powder is not just a product; it's a commitment to your well-being.
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Deep Insight on NADH: a Potential Medical Arsenal
Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen and an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repair, insulin synthesis and secretion, immune response and cell division, playing a critical role in promoting health span and mitigating various disease states. Major enzymatic reactions in substrate metabolism that are dependent upon NAD+/NADH ratio The equilibrium of the NAD+/NADH ratio is vital for maintaining cellular reduction–oxidation (redox) homeostasis and modulating energy metabolism. Several enzymatic reactions in substrate metabolism are carried out in a NAD+/NADH ratio-dependent way. For instance, ketones suppress the increased mitochondrial production of ROS associated with excitotoxic injury by enhancing NADH oxidation (i.e. elevated NAD+/NADH ratio) in the electron transport chain, directly affecting NADH level . NADH in Krebs cycle and glycolysis NADH is produced in glycolysis and the Krebs cycle (also known as citric acid cycle or tricarboxylic acid cycle), which can transfer energy to supply ATP synthesis through the process of oxidative phosphorylation in the inner membrane of the mitochondria. Krebs cycle supplies NADH as an electron carrier to the electron transport chain in mitochondria, while glycolysis-produced NADH can be used by L-lactate dehydrogenase (LDH) or transported to the mitochondria for redox homeostasis. The effects of NADH on the mitochondria are accomplished by specialized shuttle systems (e.g., malate-aspartate or glycerol-3-phosphate). The possible strategies to modulate NADH level The main NAD/NADH biosynthetic pathways include de novo synthesis from tryptophan (TRP), synthesis from either form of vitamin B3, nicotinamide (NAM) or nicotinic acid (NA), or conversion of nicotinamide riboside (NR). Correspondingly, NADH level can be regulated by replenishing NADH precursors (eg. NR and NMN), applying NADH dehydrogenase inhibitors, having diets rich in certain nutrients (eg. vitamin B3), administrating mitochondrial targeting agents and supplementing exogenous NADH. Conclusion NADH may be a versatile therapeutic candidate by leverage of its ability to affect redox homeostasis, mitochondrial functions, and enzymatic reactions. Reference Schiuma G, Lara D, Clement J, Narducci M, Rizzo R. NADH: the redox sensor in aging-related disorders. Antioxid Redox Signal. Published online February 17, 2024. doi:10.1089/ars.2023.0375 BONTAC NADH BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories and over 170 global patents including 8 NADH patents. The purity of BONTAC NADH can reach over 98%. BONTAC NADH has been widely applied in anti-aging health products, diagnostic reagent raw materials, HCY Homocysteine Test Kit, Biomedical R&D, and functional food and beverage. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
The Prospect of the NAD+ Precursors in Age-related Diseases
1. Introduction Age-related NAD+ depletion affects physiological functions and contributes to various aging-related diseases. NAD+ precursors can significantly elevate NAD+ level in murine tissues, effectively mitigate metabolic syndrome, enhance cardiovascular health, protect against neurodegeneration, and boost muscular strength, with broad prospect in the anti-aging-related field. 2. The synthesis and metabolism of NAD+ in age-related pathologies NAD+ is synthesized from NAD+ precursors and amino acids tryptophan via three main pathways: De novo, Preiss-Handler, and Salvage. Supplementation of NAD+ precursors can be advantageous in maintaining normal cellular metabolism regulated by NAD+ and NAD+-dependent enzymes such as Sirtuins, PARP, CD38, and SARM1. NAD+ intermediates require conversion into NA to elevate NAD+ level. NAD+ and its metabolism-related enzymes have very important roles in biological processes such as cellular metabolic processes, gene expression, apoptosis and carcinogenesis. NAD+ repletion is drawing attention as an anti-aging intervention. NAD+ precursors, such as NA, NAM, NR, and NMN, provide beneficial effects in various preclinical disease models of age-induced deficits, including metabolic disorders, cardiovascular, neurodegenerative diseases, and musculoskeletal diseases. 3. Comparison on the efficacy of replenishing NAD precursors in pre-clinical studies and clinical studies in age-related pathologies The downregulation of NAD+ level in cells and tissues is not a universal phenomenon for aging-related pathologies. NAD+ merely decreases with age in certain tissues. The efficacy of NAD+ precursors in clinical studies has been limited in comparison with that in the pre-clinical studies. Noteworthily, this issue can be addressed as long as much attention has been paid to the metabolism of NAD. With regards to the oral supplementation of NAD+ precursors, there is obvious link between NAD metabolism and gut microbes. Specifically, oral consumption of NMN is converted into NAMN through interaction with the gut microbiome. In addition, dietary NAM and NR are converted into NA through gut microbiota. 4. Future research directions regarding the NAD+ metabolism It is fundamental to consider how the gut microbiome affects NAD+ metabolism, and changes in microbiome composition may affect the availability of NAD+ precursors. Future studies also require the comparative analysis of different precursors, and the role of gut microbiomes regarding various intermediaries needs to be investigated. Assessment of how NAD+ precursors affect microbiota and how their interaction with NAD+ metabolism benefits the physiological condition is essential for future preclinical and clinical studies. 5. Conclusion Supplementation of suitable NAD+ precursors or intervening in NAD+ metabolism can restore the body's NAD+ level, which is of great practical significance for effectively improving aging-related diseases and prolonging healthy life span is of great practical significance for effectively improving aging-related diseases and prolonging healthy life span. NAD metabolism involves gut microbiome, and in-depth research on their interaction is possibly an important breakthrough in the future to combat aging-related pathologies. Reference Iqbal T, Nakagawa T. The therapeutic perspective of NAD+ precursors in age-related diseases. Biochem Biophys Res Commun. Published online February 2, 2024. doi:10.1016/j.bbrc.2024.149590 About BONTAC BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 160 global patents as well as strong R&D team consisting of Doctors and Masters. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NAD and its precursors (eg. NMN and NR), with various forms to be selected (eg. endoxin-free IVD-grade NAD, Na-free or Na-containing NAD; NR-CL or NR-Malate). High quality and stable supply of products can be better ensured here with the exclusive Bonpure seven-step purification technology and Bonzyme Whole-enzymatic method. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. BONTAC holds no responsibility for any claims, damages, losses, expenses, costs or liabilities whatsoever resulting or arising directly or indirectly from your reliance on the information and material on this website.
The 20th World Pharmaceutical Raw Materials China Exhibition
From December 16 to 18,2020, the 20th World Pharmaceutical Raw Materials China Exhibition (CPhI China 2020) was successfully held in Shanghai New International Expo Center. Bangtai Biological Engineering (Shenzhen) Co., Ltd. (hereinafter referred to as "BONTAC"), as an important exhibitor, with the company NADH, NAD and other star products in the E4F38 booth hardcore debut.